ISIS-2 Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction:ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet 1988 Aug 13;2(8607):349-60.
RISC Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. The RISC Group. Lancet 1990 Oct 6;336(8719):827-30.
Juul Möller Juul-Moller S, Edvardsson N, Jahnmatz B, Rosen A, Sorensen S, Omblus R. Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group. Lancet 1992 Dec 12;340(8833):1421-5.
CURE Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001 Aug 16;345(7):494-502.
Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events (CHARISMA). N Engl J Med 2006;354.
PLATO Wallentin L, Harrington R et al, Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes, N Engl J Med 2009;361:1045-1057
PEGASUS Bonaca, M.P., et al., Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction. New England Journal of Medicine, 2015. 372(19): p. 1791-1800
Gilard, M., et al., Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin. J Thromb Haemost, 2006;4(11):2508-9
Gilard, M., et al., Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole Clopidogrel Aspirin) study. J Am Coll Cardiol, 2008;51(3):256-60
Frere, C., et al., Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome. Am J Cardiol, 2008;101(8):1088-93
Aubert, R.E., et al., Abstract 3998: Proton Pump Inhibitors Effect on Clopidogrel Effectiveness: The Clopidogrel Medco Outcomes Study. Circulation, 2008;101(8):1088-93
Ho, P.M., et al., Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome. JAMA 2008;101(8)
O’Donoghue, M.L., et al., Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet 2009;374()694):989-97
Ho, P.M., et al., Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. JAMA 2008;299(5):532-9
FDA, Early Communication about an Ongoing Safety Review of clopidogrel bisulfate (marketed as Plavix). 2009. IRF, Ringe klinisk betydning af interaktion mellem PPI og clopidogrel. 2009.
